Endocrine Abstracts

Background: Fibroblast growth factor 21 (FGF21) is a hormone induced in the liver by metabolic stressors including starvation, sugars, and ethanol. Alcohol consumption increases endogenous FGF21 levels in humans while administration of FGF21 has been shown to reduce alcohol consumption in non-human primates. The effect of acute moderate alcohol consumption and long-term alcohol cessation on FGF21 levels in humans is controversial. We hypothesize that even moderate alcohol cons...